The Buffalo Bills enter the 2026 season with renewed energy, a strong defensive core, and a developing offense behind an upgraded secondary. After an opening-week win over the Lions, let’s take a look at how the rest of the season could unfold.
Week 1 – vs Lions
Result: Bills 24, Lions 20 ✅ (1–0)
The defense made clutch plays late, holding off Detroit’s high-powered attack. A statement win to open the year.
Week 2 – vs Dolphins
Prediction: Bills 31, Dolphins 27
Miami’s speed always challenges Buffalo, but the Bills’ improved coverage and balance on offense prove enough. Josh Allen outduels Tua in a shootout to start divisional play 2–0.
Week 3 – @ Jets
Prediction: Bills 20, Jets 17
A gritty defensive battle. Riley Moss makes his mark with a red zone interception, sealing another close divisional victory.
Week 4 – @ Patriots
Prediction: Bills 27, Patriots 13
Buffalo dominates the struggling Pats, controlling time of possession and forcing turnovers. The secondary shines against a young quarterback.
Week 5 – @ Dolphins
Prediction: Dolphins 28, Bills 24
The rematch goes Miami’s way. Tyreek Hill breaks free late, exposing Buffalo’s deep coverage once. A tough but teachable road loss.
Week 6 – vs Chiefs
Prediction: Chiefs 35, Bills 31
Classic Allen vs. Mahomes thriller. The Bills’ offense clicks, but Kansas City’s late-game magic prevails again. Buffalo drops to 4–2 entering the bye.
Week 7 – BYE WEEK
A perfect time to reset, especially with the defense needing adjustments against elite passing teams.
Week 8 – vs Patriots
Prediction: Bills 28, Patriots 10
Fresh off the bye, the Bills sweep New England and reassert dominance in the AFC East.
Week 9 – vs Packers
Prediction: Bills 33, Packers 21
Buffalo’s defensive front overwhelms Green Bay’s line. Look for a breakout game from rookie RB L.J. Martin in this one.
Week 10 – @ Bears
Prediction: Bills 27, Bears 17
Cold weather football favors Buffalo. The defense suffocates Chicago’s passing game while Allen and Diggs grind out points.
Week 11 – @ Seahawks
Prediction: Seahawks 24, Bills 23
West coast trap game. A late special teams miscue costs Buffalo in a tough road loss.
Week 12 – vs Vikings
Prediction: Bills 31, Vikings 14
A bounce-back blowout. The Bills’ zone coverage confuses Minnesota’s QB all afternoon. Moss grabs his second interception of the season.
Week 13 – vs Jets
Prediction: Bills 23, Jets 20
Another tight divisional contest, but Allen’s late heroics and a clutch Benford pass breakup preserve the win.
Week 14 – vs Colts
Prediction: Bills 28, Colts 24
The Colts push hard behind their run game, but Buffalo’s linebackers stand tall in crunch time.
Week 15 – vs Broncos
Prediction: Bills 34, Broncos 17
Revenge game for Riley Moss. Expect an interception and some fire against his old team. Buffalo rolls to 10–3.
Week 16 – @ Ravens
Prediction: Ravens 27, Bills 21
Lamar Jackson’s mobility causes problems, and the Bills’ offense struggles to keep up in Baltimore’s tough December conditions.
Week 17 – @ Raiders
Prediction: Bills 30, Raiders 20
Buffalo bounces back with a clean road win. The defense forces two turnovers, and rookie LG Tomas Rimac anchors a strong run game.
Week 18 – vs Chargers
Prediction: Bills 24, Chargers 21
Playoff vibes in Orchard Park. The Bills’ defense steps up big in the finale to finish strong.
Final Record Prediction: 12–5
This defense can finally complement Josh Allen’s firepower.
